MMP-2/MMP-9 Inhibitor I

Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Target IC₅₀: 310 nM and 240 nM against MMP-2 and MMP-9

Primary TargetMMP-2, MMP-9

General description

A potent inhibitor of MMP-2 (IC₅₀ = 310 nM) and MMP-9 (IC₅₀ = 240 nM). Orally active in animal models of tumor growth and metastasis.

A potent inhibitor of MMP-2 (gelatinase A; IC₅₀ = 310 nM) and MMP-9 (gelatinase B; IC₅₀ = 240 nM).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Tamura, Y., et al. 1998. J. Med. Chem.41, 640.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Standard Handling (A)